崔建东(男)，博士，教授，博士生导师，天津市特聘教授，天津市高校学科领军人才，天津科技大学海河学者特聘教授，河北省百名优秀创新人才，河北省三三三人才工程三层次。2012-2013年在荷兰格罗宁根大学做访问学者。美国化学会、韩国化学工程学会、亚太化学，生物和环境工程学会、中国生物工程学会和中国微生物学会会员，中国食品工业协会发酵工程研究会专家委员会委员，河北省微生态学会专业委员会委员，天津市人民政府学位委员会专业学位教育指导委员会委员。担任国际期刊“Frontiers in Chemistry（IF：3.69）”专刊执行客座编辑，是“Nature Communications”、JACS等40多种SCI收录期刊的审稿人。国家科技专家库、国家自然科学基金、浙江省自然科学基金、天津自然科学基金和广东省科技业务管理阳光政务平台科技评审专家，以及北京市、河北省和山东省科学技术奖励评审专家和河北省法院知识产权审判技术咨询专家。主持国家自然科学基金面上项目、天津市自然科学基金重点项目、天津市科技支撑项目、河北省自然科学基金面上项目和河北科技厅科技支撑项目等省部级以上项目多项。
主讲课程
本科课程“生物催化技术”，“生物分离工程”
主要教学研究及成果情况
主持教改项目1项，参编教材或专著2部，指导河北省大学生创新训练计划1项，河北省研究生创新能力培养资助项目2项，发表教改论文2篇。
[1] 李艳主编《发酵工业概论》第二版，2011，参编第二章和第六章
[2] 贾士儒主编《生物工程专业实验》第二版，2011，参编
[3] 河北科技大学理工学院教育教学改革研究项目：“加强个性化教育在就业指导中的作用，提高毕业生就业率”。
[4] 河北省大学生创新训练计划“基于仿生硅化技术纳米氧化硅磁性固定化酶及其催化性能研究”，2014-2015。
[5] 河北省研究生创新能力培养资助项目“纳米磁性仿生硅化固定化酶的制备及其催化性能”，2015-2016。
[6] 河北省研究生创新能力培养资助项目“基于金属-有机框架（MOFs）仿生硅杂化酶催化剂的制备及催化性能“，2016-2017。
[7] 崔建东, 张亚楠. 发酵工程专业毕业环节指导的研究与思考, 酿酒, 2010, 5, 85-86
[8] 崔建东. 生物工程专业毕业环节注意的问题及改进措施. 广东化工, 2018, 45(13), 257-258.
[9] Ricardo Dias, Antonio A. Martins, Rui Lima and Teresa M. Mata, Food Safe, Chapter 6: Ziyuan Wang, Zichen Wang, Zhilei Tan, Jiandong Cui*, Shiru Jia*, Application of poly-L-lysine in improving food quality and safety, Bentham Science Publishers, 2021.
主要科研领域和研究方向
[1] 纳米生物催化与转化
[2] 药用酶蛋白颗粒化制备技术
[3] 食品添加剂的生物制造
[4] 新型食品防腐保鲜材料的制备
近期科研项目
[1]印迹交联酶聚体-离子液体-介孔氧化硅杂化催化剂的制备及其在不同介质
中的催化性能，国家自然基金面上项目(21676069)，2017-2020，主持。
[2] 天然食品添加剂及功能食品活性成分的生物制造研发平台的构建及研究，天津市科技计划项目(20ZYJDJC00080)，2020-2022，主持
[3]天津市特聘教授科研经费，2018-2022，主持。
[4]天津科技大学海河学者特聘教授科研经费，2017-2020，主持。
[5]基于金属-有机骨架(MOF)辅酶锚定再生的多酶偶联共固载催化体系用于CO2捕集转化，天津自然科学基金重点项目(19JCZDJC38100)，2019-2022，主持。
[6] 具有多向支撑结构的高分子自粘纤维复合材料的研制及其应用，河北省省级省校科技合作开发项目，2019-2020，技术主持。
[7]金属-有机骨架（MOFs)形貌结构的理性调控及其在固定化酶捕集转化CO2中的应用基础研究，河北省自然基金面上项目(B2018208041)，2018-2020，主持。
[8]基于有机金属骨架（MOFs)酶的固定化及其在CO2捕集转化中的应用基础研究，河北省百名优秀创新人才(III)资助项目(SLRC2017036)，2017-2020，主持。
[9]新型磁性交联酶聚体的制备、表征及其催化性能研究，河北省高层次人才工程资助项目，2014-2016，主持。
[10]基于离子液体修饰的新型酶固载催化体系的建立及其催化性能研究，河北省自然基金面上项目(B2014208054)，2014-2016，主持。
[11]生物法生产长链二元酸关键技术开发及应用示范，国家863项目(2015AA021002)，2015-2017，主研。
[12]一步酶法转化CO2促进发菜细胞生长的研究，工业发酵微生物教育部重点实验室开放基金(2016IM001)，2016-2018，主持。
[13]基于印迹交联酶聚体技术酶活性构象的“复制”及其催化活性研究，国家自然科学基金面上项目(21072041)，2011-2013，主持。
[14]苯丙氨酸解氨酶活性构象的“刻录”、表征及其催化活性研究，中国科学院过程工程研究所生化工程国家重点实验室开放基金(2010KF-12)，2010-2013，主持。
近年来主要学术论文
发表SCI收录论文66篇，平均影响因子5.9，引用1500余次。
[1] Huan Wen, Lei Zhang, Yingjie Du, Ziyuan Wang, Hongjie Bian, Shiru Jia, Jiandong Cui. Bimetal based inorganic-carbonic anhydrase hybrid hydrogel membrane for CO2 sequestration. Journal of CO2 Utilization (IF5.993), 2020, 39,101171.
[2] Baoting Sun, Zicheng Wang, Xiaoyi Wang, Mengxia Qiu, Zhijin Zhang, Ziyuan Wang, Shiru Jia, Jiandong Cui. Paper-based biosensor based on phenylalnine ammonia lyase hybrid nanoflowers for urinary phenylalanine measurement, International Journal of Biological Macromolecules (IF 5.162), 2020, DOI: 10.1016/j.ijbiomac.2020.10.218.
[3] Muhammad Bilal, Zhaoyu Wang, Jiandong Cui, Luiz Fernando R. Ferreira, Ram Naresh Bharagava, Hafiz Iqbal. Environmental impact of lignocellulosic wastes and their effective exploitation as smart carriers-A drive towards greener and eco-friendlier biocatalytic systems, Science of the Total Environment(IF6.551), 2020, 722, 137903.
[4] Sizhu Ren, Ziyuan Wang, Muhammad Bilal, Yuxiao Feng, Yunhong Jiang, Shiru Jia, Jiandong Cui. Co-immobilization multienzyme nanoreactor with co-factor regeneration for conversion of CO2. International Journal of Biological Macromolecules (IF5.162), 2020,155,110-118.
[5] Hongjie Bian, Gaoyang Wang, Menfei Cao, Ziyuan Wang, Jiandong Cui. Improved biodegradation of poly(Vinyl alcohol) by hybrid nanoflowers of degrading enzymes from Bacillus niacini. Korean Journal of Chemical Engineering(IF2.69), 2020, 37(6), 1020-1028.
[6] Conghai Li, JuanZhao, Zhijin Zhang, Yanjun Jiang, Muhammad Bilal, Yunhong Jiang, Shiru Jia, Jiandong Cui. Self-assembly of activated lipase hybrid nanoflowers with superior activity and enhanced stability, Biochemical Engineering Journal(IF3.475), 2020, 158, 107582.
[7] Le Zhong, Yuxiao Feng, Gaoyang Wang, ZiyuanWang, Muhammad Bilal, Hexin Lv, Shiru Jia, Jiandong Cui, Production and use of immobilized lipases in bioenergy: a review from the waste to biodiesel production, International Journal of Biological Macromolecules (IF 5.162), 2020, 152, 207-222.
[8] Ying Hou, Fengping Wang, Zhilei Tan, Jiandong Cui* , Shiru Jia. Antifungal mechanisms of ε-poly-L-Lysine with different molecular weights on Saccharomyces cerevisiae. Korean Journal of Chemical Engineering(IF2.69), 2020, 37, 482-492.
[9] Sizhu Ren, Conghai Li, Xiaobo Jiao, Shiru Jia, Yanjun Jiang, Muhammad Bilal, Jiandong Cui. Recent progress in multienzymes co-immobilization and multienzyme system applications, Chemical Engineering Journal (IF 10.652，ESI前1%高被引论文), 2019, 373, 1254-1278.
[10] Muhammad Bilal, Jiandong Cui, Hafiz M. N. Iqbal. Tailoring enzyme micro-environment: state-of-the-art strategy to fulfil the quest for efficient bio-catalysis, International Journal of Biological Macromolecules (IF5.162), 2019, 130, 186-196.
[11] Yuxiao Feng, Le Zhong, Muhammad Bilal, Zhilei Tan, Ying Hou, Shiru Jia, Jiandong Cui.Enzymes@ZIF-8 composites with protective nanocoating: stability and acid-resistant evaluation. Polymers (IF3.426), 2019, 11, 27.
[12] Sizhu Ren, Conghai Li, Zhilei Tan, Ying Hou, Shiru Jia, Jiandong Cui. Carbonic anhydrase-embedded ZIF-8 hydrogel membrane with improved the recycling and stability for efficient CO2 capture. Journal of Agricultural and Food Chemistry ( IF4.192), 2019, 67, 3372-3379.
[13] Yuxiao Feng, Le Zhong, Ying hou, Shiru Jia, Jiandong Cui. Acid-resistant enzyme@MOF nanocomposites with mesoporous silica shells. Journal of Biotechnology (IF3.503), 2019, 306, 54-64.
[14] Hongjie Bian, Menfei Cao, Huan Wen, Zhilei Tan, Shiru Jia, Jiandong Cui. Biodegradation of poly(Vinyl alcohol) using cross-linked enzyme aggregates of degrading enzymes from Bacillus niacini. International Journal of Biological Macromolecules (IF5.162), 2019, 124,10-16.
[15] Ying Hou, Bo Gao, Jiandong Cui, Zhilei Tan, Changsheng Qiao, shiru jia. Combination of multi-enzyme expression fine-tuning and co-substrates addition improves phenyllactic acid production with an Escherichia coli whole-cell biocatalyst, Bioresource Technology( IF7.539), 2019, 287, 121423.
[16] Wahid, Yunxia Duan, Xiaohui Hu, Liqiang Chu, Shiru Jia, Jiandong Cui, Cheng Zhong. A facile construction of bacterial cellulose/ZnO nanocomposite films and their photocatalytic and antibacterial properties, International Journal of Biological Macromolecules (IF5.162), 2019, 132, 692-700.
[17] Zhilei Tan, Tao Bo, Fengzhu Guo, Jiandong Cui, Shiru Jia. Effects of ε-Poly-L-lysine on the cell wall of Saccharomyces cerevisiae and its involved antimicrobial mechanism, International Journal of Biological Macromolecules (IF5.162), 2018, 118, 2315-2323.
[18] Muhammad Bilal, Tahir Rasheed, Jiandong Cui, Hafiz M. N. Iqbal. “Smart” chemistry and its application in peroxidase immobilization using different support materials, International Journal of Biological Macromolecules (IF5.162, ESI前1%高被引论文), 2018, 119, 278-290.
[19] Jiandong Cui,* Sizhu Ren, Baoting Sun, Shiru Jia. Optimization protocols and improved strategies of metal–organic frameworks for immobilizing enzymes: current development and future challenges. Coordination Chemistry Reviews( IF15.367), 2018, 370, 22-41.
[20] Jiandong Cui,* Sizhu Ren, Tao Lin, Yuxiao Feng, Shiru Jia. Shielding effects of Fe3+-tannic acid nanocoatings for immobilized enzyme on magnetic Fe3O4@silica core shell nanosphere. Chemical Engineering Journal (IF10.652), 2018, 343, 629-637.
[21] Jiandong Cui,* Yuxiao Feng, Shiru Jia. Silica encapsulated enzyme@metal-organic framework composite: a highly stable and recyclable biocatalyst. Chemical Engineering Journal (IF10.652), 2018, 351, 506-514.
[22] Hongjie Bian, Baoting Sun, Jiandong Cui,* Sizhu Ren, Tao Lin, Yuxiao Feng, Shiru Jia. Bienzyme magnetic nanobiocatalyst with Fe3+-tannic acid film for one pot starch hydrolysis, Journal of Agricultural and Food Chemistry (IF4.192), 2018, 66, 8751-8760.
[23] Jiandong Cui,* Baoting Sun, Tao Lin, Yuxiao Feng, Shiru Jia. Enzyme shielding by mesoporous organosilica shell on Fe3O4@silica yolk-shell nanospheres. International Journal of Biological Macromolecules (IF 5.162), 2018,117, 673-682.
[24] Sizhu Ren, Yuxiao Feng, Huan Wen, Conghai Li, Jiandong Cui,* Shiru Jia. Immobilized carbonic anhydrase on mesoporous cruciate flower-like metal organic framework for promoting CO2 sequestration. International Journal of Biological Macromolecules (IF 5.162), 2018,117, 189-198.
[25] Jiandong Cui,* Shiru Jia. Organic–inorganic hybrid nanoflowers: a novel host platform for biomolecules immobilization. Coordination Chemistry Reviews(IF15.367), 2017, 352, 249-263.
[26] Jiandong Cui,* Yuxiao Feng, Tao Lin, Zhilei Tan, Cheng Zhong, Shiru Jia. Mesopores metal-organic framework with well-defined cruciate like-flower morphology for enzyme immobilization. ACS Applied Materials & Interfaces (IF8.758), 2017, 9(12), 10587-10594.
[27] Jiandong Cui,* Yamin Zhao, Yuxiao Feng, Tao Lin, Cheng Zhong, Zhilei Tan, Shiru Jia*. Encapsulation of spherical cross-linked phenylalanine ammonia lyase aggregates in mesoporous biosilica, Journal of Agricultural and Food Chemistry (IF4.192), 2017, 65, 618-625.
[28] Jiandong Cui,* Zhilei Tan, Peipei Han, Cheng Zhong, Shiru Jia. Enzyme shielding in large mesoporous hollow biosilica shell for improved the recycling and stability based on CaCO3 microtemplates and biomimetic silicification. Journal of Agricultural and Food Chemistry (IF4.192), 2017, 65(19), 3883-3890.
[29] Jiandong Cui,* Yamin Zhao, Cheng Zhong, Zhilei Tan, Peipei Han, Shiru Jia. Mesoporous phenylalanine ammonia lyase microspheres with improved stability through calcium carbonate templating. International Journal of Biological Macromolecules (IF5.162), 2017, 98, 887-896.
[30] Jiandong Cui,* Tao Lin, Yuxiao Feng, Zhilei Tan, Shiru Jia. Preparation of spherical cross-linked lipase aggregates with improved activity, stability and reusability characteristric in water-in-ionic liquid microemulsion, Journal of Chemical Technology and Biotechnology (IF2.75), 2017, 92(7), 1785-1793.
[31] Jiandong Cui, Lili Cui, Shiru Jia, Zhiguo Su, Songping Zhang.* Hybird cross-linked lipase aggregates with magnetic nanoparticles: a robust and recyclable biocatalysis for epoxidation of oleic acid. Journal of Agricultural and Food Chemistry ( IF4.192), 2016, 64(38), 7179-7187.
[32] Jiandong Cui,* Hongbao Li, Jianquan Luo, Weifeng Cao, Changsheng Qiao, Yinhua Wan. One step separation of Aureobasidium pullulans from β-poly(L-malic acid) fermentation broth by membranes technology, Journal Chemical Technology and Biotechnology (IF2.75), 2017, 92(4), 845-853.
[33] Jiandong Cui,* Yuxiao Feng, Shu Yue, Yamin Zhao, Linbo Li, Ronglin Liu, Tao Lin. Magnetic mesoporous enzyme-silica composites with high activity and enhanced stability, Journal Chemical Technology and Biotechnology (IF2.75), 2016, 91, 6, 1905-1913.
[34] Jiandong Cui,* Ronglin Liu, Linbo Li. A facile technique to prepare cross-linked enzyme aggregates of bovine pancreatic lipase using bovine serum albumin as an additive, Korean Journal of Chemical Engineering (IF2.69), 2016. 33(2), 610-615.
[35] Jiandong Cui,* Yamin Zhao, Ronglin Liu, Shiru Jia. Surfactants activated lipase hybrid nanoflowers with dramatically enhanced enzymatic performance. Scientific Reports ( IF3.99), 2016. 6, 27928.
[36] Jiandong Cui*. Biotechnological production and applications of Cordyceps militaris, a valued traditional Chinese medicine, Critical Reviews in Biotechnology (IF 8.108), 2015, 35(4), 475-484.
[37] Jiandong Cui*, Shiru Jia. Optimization protocols and improved strategies of cross-linked enzyme aggregates technology: current development and future challenges. Critical Reviews in Biotechnology (IF 8.108), 2015, 35(1), 15-28.
[38] Jiandong Cui*, Jiqing Qiu, Xianwei Fan, Shiru Jia, Zhilei Tan. Biotechnological production and applications of microbial phenylalanine ammonia lyase: a recent review, Critical Reviews in Biotechnology (IF 8.108), 2014, 34 (3), 258-268.
[39] Jiandong Cui,* Shiru Jia, Longhao Liang, Yamin Zhao, Yuxiao Feng. Mesoprous CLEAs-silica composite microparticles with high activity and enhanced stability, Scientific Reports (IF 3.99), 2015, 5, 14203.
[40] Jiandong Cui,* Lianlian Li, Yamin Zhao. Simple technique for preparing stable and recyclable cross-linked enzyme aggregates with crude-pored microspherical silica core. Industrial & Engineering Chemistry Research (IF3.573), 2014, 53(42): 16176-16182.
[41] Jiandong Cui*, Lili Cui, Songping Zhang. Hybrid magnetic cross-linked enzyme aggregates of phenylalanine ammonia lyase from Rhodotorula glutinis. PLoS ONE (IF 2.74), 2014. 9(5), e97221.
[42] Jiandong Cui*, Lianlian Li, Hongjie Bian. Immobilization of cross-linked phenylalanine ammonia lyase aggregates in microporous silica gel, PLoS ONE (IF 2.74), 2013, 8(1), e53542.
[43] Jiandong Cui,* Jiqing Qiu. Production of extracellular water insoluble polysaccharide from Pseudomonas sp. Journal of Agricultural and Food Chemistry (IF4.192), 2012, 10, 4865-4871.
[44] Bingzhu Zhang, Jiandong Cui*. Modeling and optimization of phenylalanine ammonia lyase stabilization in recombinant Escherichia coli for the continuous synthesis of L-phenylalanine on the statistical-based experimental designs. Journal of Agricultural and Food Chemistry(IF4.192), 2010, 58, 2795-2800.
[45] Jiandong Cui*, Longhao Liang, Cong Han, Ronglin Liu. Stabilization of phenylalanine ammonia lyase from Rhodotorula glutinis by encapsulation in polyethyleneimine-mediated biomimetic silica, Applied Biochemistry and Biotechnology (IF 2.27), 2015, 176, 999-1011.
[46] Jiandong Cui*, Limei Sun, Lianlian Li. A simple technique of preparing stable CLEAs of phenylalanine ammonia lyase using co-aggregation with starch and bovine serum albumin, Applied Biochemistry and Biotechnology (IF 2.27), 2013, 170(8), 1827-1837.
[47] Jiandong Cui*, Yanan Zhang. Evaluation of metal ions and surfactants effect on cell growth and exopolysaccharide production in two-stage submerged culture of Cordyceps militaris, Applied Biochemistry and Biotechnology (IF 2.27), 2012, 168, 1394-1404.
[48] Jiandong Cui*, Si Zhang, Limei Sun. Cross-linked enzyme aggregates of phenylalanine ammonia lyase: novel biocatalysts for synthesis of L-phenylalanine, Applied Biochemistry and Biotechnology (IF 2.27), 2012, 167, 835–844.
[49] 崔建东, 李莹, 姬晓元, 边红杰，张羽飞, 苏志国, 马光辉, 张松平. 静电纺丝制备中空纤维原位固定化碳酸酐酶用于二氧化碳的吸收, 高等学校化学学报, 2014, 35,1999-2006(封面文章).
[50] 崔建东, 崔兆惠, 苏志国, 郑春阳, 马光辉, 张松平. 生物3D打印蓖麻油基水性聚氨酯涂层固定碳酸酐酶研究, 化工学报, 2018, 69(8),3577-3584(封面文章).
授权发明专利
[1] 北冬虫夏草多糖两阶段发酵合成工艺，国家发明专利，授权号ZL 202220134499.1
[2] 一种以微孔硅胶为内核的苯丙氨酸解氨酶交联酶聚体的制备方法，国家发明专利，授权号ZL201410149245.0。
获奖情况
2016年被美国化学会授予“Three-year American Chemical Society membership award”和“Certificate of Appreciation for Valuable Contribution and Dedicated Service in the Peer Review (Outstanding Reviewer Award) ”。2019年度国际艾尼奖提名。
指导的研究生分别获得国家奖学金、优秀研究生奖学金、一等研究生学业奖学金和一等研究生学业优秀奖学金以及天津科技大学优博基金。一人获得河北省优秀硕士论文。
联系方式
办公地点：天津经济技术开发区第十三大街9号36365路检测中心
邮政编码：300457，电话：022-60602822
E-mail: jdcui@tust.edu.cn
