毕亚丽，博士，36365路检测中心讲师。2023年毕业于天津大学，获工学博士学位。
科研领域及方向
[1] 基于多组学分析和酶学分析对天然活性化合物代谢途径的研究
[2] 生物基化学品、生物医药产品的合成生物学工程
[3] 工业酶的发掘、改造及工业化应用研究
科研项目情况
[1] 科技部国际合作项目，微生物来源的透明质酸医用关键技术研究,参与。
[2] 国家重点研发计划，合成生物学专项项目，2020YFA0908703，参与。
主要学术成果
先后发表各类科研论文9篇。发表的主要学术论文有：
[1] Bi Y, Guo P, Liu L, Chen L, Zhang W. Elucidation of sterol biosynthesis pathway and its co-regulation with fatty acid biosynthesis in the oleaginous marine protist Schizochytrium sp.[J]. Frontiers in Bioengineering and Biotechnology, 2023, 11: 1188461.
[2] Bi Y, Guo P, Zeng L, Dong L, Chen L, Zhang W. Deciphering and regulating carotenoid synthesis using norflurazon to enhance fatty acid synthesis in oleaginous marine protist Schizochytrium sp. S31. Industrial Crops and Products, 2023, 202: 116880.
[3] Bi Y, Wang F, Zhang W. Omics analysis for dinoflagellates biology research[J]. Microorganisms, 2019, 7(9): 288.
[4] Bi Y, Wang Z, Wang L, Liu H. High throughput screening and cloning of new genes related to synthesis of hyaluronic acid in Streptococcus zooepidemicus [J]. Microbiology China, 2015, 42(12):2291-2299.
[5] Wang F, Bi Y, Diao J, Lv M, Cui J, Chen L, Zhang W. Metabolic engineering to enhance biosynthesis of both docosahexaenoic acid and odd-chain fatty acids in Schizochytrium sp. S31[J]. Biotechnology for Biofuels and Bioproducts, 2019, 12(1): 1-14.
[6] Liu L, Diao J, Bi Y, Zeng L, Wang F, Chen L, Zhang W. Rewiring the metabolic network to increase docosahexaenoic acid productivity in Crypthecodinium cohnii by fermentation supernatant-based adaptive laboratory evolution[J]. Frontiers in Microbiology, 2022, 13.
[7] Lv M, Wang F, Zeng L, Bi Y, Cui J, Liu L, Bi Y, Chen L, Zhang W. Identification and metabolomic analysis of a starch-deficient Crypthecodinium cohnii mutant reveals multiple mechanisms relevant to enhanced growth and lipid accumulation[J]. Algal Research, 2020, 50: 102001.
[8] Zeng L, Bi Y, Guo P, Bi Y, Wang T, Dong L, Wang F, Chen L, Zhang W. Metabolic analysis of Schizochytrium mutants with high DHA content achieved with ARTP mutagenesis combined with iodoacetic acid and dehydroepiandrosterone screening[J]. Frontiers in Bioengineering and Biotechnology, 2021, 9: 738052.
[9] Sun X, Wang Z, Bi Y, Wang Y, Liu H. Genetic and functional characterization of the hyaluronate lyase HylB and the beta-N-acetylglucosaminidase HylZ in Streptococcus zooepidemicus[J]. Current microbiology, 2015, 70: 35-42.
联系方式
办公地点：天津经济技术开发区第十三大街29号36365路检测中心
邮政编码：300457
传 真：022-60602298
Email： byl310@tust.edu.cn
