张欢，博士，助理研究员，毕业于南开大学，2023年加入36365路检测中心现代酿造研究室。
科研领域及方向
[1]发酵产品风味分析
[2]肠道微生物
科研项目情况
[1] 中国博士后科学基金（特别资助） 新冠疫情防控专项资助，2020-2023年，18万，项目编号：2020T130093ZX（主持）
[2] 国家自然科学基金 基于NFKB信号网络调控的清络饮抗血管新生药效物质研究研究，2013-2016（参与）
[3] 国家自然科学基金 基于构效关系的神经降压素受体1拮抗剂优化，2012-2015（参与）
主要学术成果
先后发表各类科研论文13篇，授权发明专利1项。发表的主要学术论文有：
[1] Zhang H, Kang J , Guo W, et al. An optimal medicinal and edible Chinese herbal formula attenuates particulate matter-induced lung injury through its anti-oxidative, anti-inflammatory and anti-apoptosis activities. Chinese Herbal Medicines.（in press）
[2] Zhang H, Song X, Wang P, Lv R, Ma S, Jiang L. YaeB, Expressed in Response to the Acidic pH in Macrophages, Promotes Intracellular Replication and Virulence of Salmonella Typhimurium. International Journal of Molecular Sciences 2019;20:4339-4355.
[3] Zhang H, Song X, Lv R, Liu X, Wang P, Jiang L. The LysR-type transcriptional regulator STM0030 contributes to Salmonella Typhimurium growth in macrophages and virulence in mice. Journal of Basic Microbiology 2019; 59:1143–1153.
[4] Zhang H, Wang Y, Xu F. Impact of the subtle differences in MMP-12 structure on Glide-based molecular docking for pose prediction of inhibitors. Journal of Molecular Structure 2014;1076:153-159.
[5] Wang B*, Zhou W* , Zhang H*, Wang W, Zhang B, and Li S , Exploring the effect of Weifuchun capsule on the Toll-like receptor pathway mediated HES6 and immune regulation against chronic atrophic gastritis. Journal of Ethnopharmacology.2023(303):115930.
[6] Zhou W*, Zhang H*, Wang X, Kang J, Guo W, Zhou L, Liu H, Wang M, Jia R, Du X, Wang W, Zhang B., & Li S., 2022. Network pharmacology to unveil the mechanism of Moluodan in the treatment of chronic atrophic gastritis. Phytomedicine, 95, 153837.
[7] Guo W* , Zhang H*, Zhang, et al. Transport mechanism of eurycomanone from Eurycoma longifolia Jack across Caco-2 cells model[J]. Jounal of Food Bioactives, 2022, (17): 27-33.
[8] Song X*, Zhang H*, Ma S*, Song Y, Lv R, Liu X, Yang B, Huang D, Liu B, Jiang L. Transcriptome analysis of virulence gene regulation by the ATP-dependent Lon protease in Salmonella Typhimurium. Future Microbiol 2019;14:1109-1122.
[9] Song X*, Zhang H*, Liu X, Yuan J, Wang P, Lv, R, Yang B, Huang D, & Jiang L, 2019. The putative transcriptional regulator STM14_3563 facilitates Salmonella Typhimurium pathogenicity by activating virulence-related genes. International Microbiology, 1-10.
[10] Wang P*, Zhang H*, Liu Y*, Lv R, Liu X, Song X, Wang J, & Jiang L, 2020. SoxS is a positive regulator of key pathogenesis genes and promotes intracellular replication and virulence of Salmonella Typhimurium. Microbial Pathogenesis, 139, 103925.
[11] Jiang L, Wang P, Song X, Zhang H, et al. Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence[J]. Nature Communications,2021,12(1).879-997.
[12] Wang Y, Wang, H, Xu K, Ni P, Zhang, H, Ma J, Yang H, Xu F. A survey of overlooked viral infections in biological experiment systems. PloS one, 2014. 9(8): p. e105348
[13]. 周丽华, 罗庆华, 马颖超, 郭武艳, 张欢, 张博.中国大鲵皮肤分泌黏液组成成分、生物活性及开发应用研究进展.世界中医药.（已接收）
授权发明专利主要有：
张博，张欢，常瑞恒，郭武艳，朱倩，陈宝贵，于美丽. 靶向抑制冠状病毒入侵复制的中药挥发油组合物极其口腔喷剂.授权公告号：CN114732849B
联系方式
办公地点：天津经济技术开发区第十三大街29号36365路检测中心
邮政编码：300457
Email： zhanghuan90@tust.edu.cn
