谢周杰 博士，36365路检测中心副研究员,硕士生导师。天津市特聘教授青年学者项目人选.
主讲课程
本科生：微生物学实验；微生物遗传与育种；
研究生：代谢工程与合成生物学
科研领域及方向
工业微生物分子育种；链霉菌次级代谢产物的生物合成与分子调控
主持科研项目
1．国家自然科学基金面上项目，31570050，变型链球菌UA159中Mutanobactins生物合成机制的研究，2016/01-2019/12
2.国家重点研发计划—海洋环境安全保障重点专项子课题，2019/12 -2021/12
代表性论文：
Yu J#, Wang Y#, Han D, Cao W, Zheng L, Xie Z*, Liu H*. (2020) Identification of Streptococcus mutans genes involved in fluoride resistance by screening of a transposon mutant library. Mol Oral Microbiol. Sep 30.
Xie Z#, Zou Z#, Raz A, Qin H, Fischetti V, Zhang S, Kreth J, Merritt J*. (2020）Regulatory control of the Streptococcus mutans HdrRM LytTR Regulatory System functions via a membrane sequestration mechanism. Mol Microbiol. Jul 24.
Wang M#, Xie Z#, Tang S#, Chang EL, Tang Y, Guo Z, Cui Y, Wu B, Ye T, Chen Y*.（2020）Reductase of Mutanobactin Synthetase Triggers Sequential C-C Macrocyclization, C-S Bond Formation, and C-C Bond Cleavage.Org Lett. Feb 7;22(3):960-964.
Hao T#, Xie Z#, Wang M, Liu L, Zhang Y, Wang W, Zhang Z, Zhao X, Li P, Guo Z, Gao S, Lou C, Zhang G, Merritt J, Horsman GP, Chen Y*.（2019）An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters. Nat Commun. Aug 14;10(1):3665.
Xie Z, Meng K, Yang X, Liu J, Yu J, Zheng C, Cao W, Liu H*. (2019) Identification of a Quorum Sensing System Regulating Capsule Polysaccharide Production and Biofilm Formation in Streptococcus zooepidemicus. Front Cell Infect Microbiol. Apr 18;9:121.
Xie Z, Zhang Z, Cao Z, Chen M, Li P, Liu W, Qin H, Zhao X, Tao Y, Chen Y*.（2017）An external substrate-free blue/white screening system in Escherichia coli. Appl Microbiol Biotechnol. May;101(9):3811-3820.
Xie Z, Qi F, Merritt J*. (2013) Development of a tunable wide-range gene induction system useful for the study of streptococcal toxin-antitoxin systems. Appl Environ Microbiol. Oct;79(20):6375-84.
Xie Z, Okinaga T, Qi F, and Merritt J*. (2011) Cloning-independent and counterselectable markerless mutagenesis system in Streptococcus mutans. Appl Environ Microbiol. Nov;77(22):8025-33.
Xie Z, Okinaga T, Niu G, Qi F, and Merritt J*. (2010) Identification of a novel bacteriocin regulatory system in Streptococcus mutans. Mol Microbiol. 78(6):1431-1447.
联系方式
办公地点：天津经济技术开发区第十三大街29号36365路检测中心 生物楼405 邮编300457
Email：zhoujiexie@tust.edu.cn
